Proton Therapy and Radiosurgery

The book is divided into two parts: Part I deals with the relevant physics and planning algorithms of protons (H Breuer) and Part II with the radiobiology, radiopathology and clinical outcomes of proton therapy and a comparison of proton therapy versus photon therapy (BJ Smit). Protons can be used for radiosurgery and general radio­ therapy. Since proton therapy was first proposed in 1946 by Wilson, about sixteen facilities have been built globally. Only a very few of these have isocentric beam delivery systems so that proton therapy is really only now in a position to be compared directly by means of randomised clinical trials, with modern photon radiotherapy therapy sys­ tems, both for radiosurgery and for general fractionated radiotherapy. Three-dimensional proton planning computer systems with image fusion (image of computerised tomography (CT), magnetic resonance registration) capabilities imaging (MRI), stereotactic angiograms and perhaps positron emission tomography (PET) are essential for accurate proton therapy planning. New planning systems for spot scanning are under development. Many of the older comparisons of the advantageous dose distributions for protons were made with parallel opposing or multiple co-planar field arrangements, which are now largely obsolete. New comparative plans are necessary once more because of the very rapid progress in 3-D conformal planning with photons. New cost-benefit analy­ ses may be needed. Low energy (about 70 MeV) proton therapy is eminently suitable for the treatment of eye tumours and has firmly established itself as very useful in this regard.

I Radiation Physics.- A General Aspects.- B Basics.- C Interaction of Protons with Matter.- D Modifying the Proton Beam.- E Conformal Proton Radiotherapy Planning.- II Proton Therapy and Radiotherapy.- F General Aspects of Proton Therapy.- G The Rationale for Proton Therapy.- H Radiobiology.- I. Dose-Volume Relationships in Proton Therapy and Radiosurgery for Arteriovenous Malformations, Skull Base Meningiomas and Recurrent Malignant Gliomas.- J Low Energy Proton Beam Therapy for Eye Lesions.- K High Energy Proton Therapy for Tumours in Body Sites other than the Brain.- L Radio surgical Applications of Protons and Photons.- M The Complications of Single Large Intracranial Doses of Radiation and their Management.- N Alternatives to Proton Therapy for Radiosurgery.- O Costs of Proton Therapy and Radiosurgery.- P Appendix.