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Synthetic Studies in Nitrogenous Compounds
Langbeschreibung
Quinazolines are well known for their pharmaceutical importance as antibacterials, antitumours, antiparkinson and also show blood platelet antiaggregating activities. The Niementowski reaction is the explored for the synthesis of 3- substituted-4(3H)quinazolinones for which anthranilic acid, formic acid and aromatic or heteroaromatic amines are irradiated using ¿neat reaction technology¿ under microwaves without any solvent. This proved to be a high yielding protocol. Further study of 4(3H)quinazolinones as another possible Niementowski reaction is done by irradiating neat reactants, anthranilic acid, aromatic or aliphatic carboxylic acids and aromatic or heteroaromatic amines in microwaves to afford 2,3-disubstituted- 4(3H)quinazolinones within few minutes of irradiation.
Dr. Shweta Rastogi is an Assistant Professor in the Department of Chemistry, Hansraj College, Univ. of Delhi, India. She has been teaching undergraduate students for over 9 years. Dr. Rastogi has to her credit 26 research publications of international and national repute. She is a member of learned bodies and is also a reviewer of the Frontiers.
ISBN-13:
9783659746154
Veröffentl:
2018
Erscheinungsdatum:
13.12.2018
Seiten:
368
Autor:
Shweta Rastogi
Gewicht:
566 g
Format:
220x150x23 mm
Sprache:
Englisch
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