New Trends in Haemostasis

To give an update in the field of haemostasis scientists andclinicians fromoverseas and European countries met to discuss the new trends in pathophysiology and clinical implications. This book is devoted to the interactions of endothelial functions, tissue factors, coagulation inhibitorsand haemostasis as well as detection and prophylaxis ofthromboembolism. Data are presented of significant new research work on molecular and clinical approaches to diseasesin haemostasis.

Endothelial Functions and Haemostasis.- Structure, Shape and Function of Glycosaminoglycans.- Structure and Metabolism of Glycosaminoglycans.- Fibrin Polymerization and Its Role in Regulating Haemostasis.- Function of von Willebrand Factor in Plasma.- Biosynthesis and Assembly of the Factor VIII - von Willebrand Factor Complex.- Modulation of Endothelial Cell Function by Hypoxia: Perturbation of Barrier and Anticoagulant Function and Induction of a Novel Procoagulant Activity.- Tissue Factors and Endothelium.- Platelet Adhesion; A Concerted Action of Hemodynamic and Biochemical Processes.- Modulation of Endothelial Functions by Advanced Glycosylation End Products.- Procogulant Activities of Leukocytes.- Cytokine Induced Stimulation of Endothelial Cells in Vitro.- Anti-Platelet Treatment of Metastasis.- The Molecular Anatomy of Vitronectin as Extracellular Regulator Protein: Multifunctional Properties of the Heparin-Binding Domain.- Mode of Action of Annexin V (Vascular Anticoagulant Alpha), A Protein Synthesized by the Vessel Wall.- Coagulation Inhibitors and Haemostasis.- Clinical Pharmacologal Profile of Low Molecular Weight Heparins.- Anticoagulant Actions of Sulphated Polysaccharides.- Development of Synthetic Proteinase Inhibitors as Anticoagulant Agents.- Antithrombin and Its Deficiency States.- "New" Coagulation Inhibitors.- Biological Function of Vitamin K Antagonists.- Plasminogen Activator Inhibitors: Biological Effects.- Fibrin-Specific Clot Lysis with Single Chain Urokinase-Type Plasminogen Activator (scu-PA).- Antibody - Mediated Thrombolysis: Promise and Problems.- Thromboembolism: Detection and Prophylaxis.- Causation and Prevention of Coronary Thrombosis: Present Situation.- Non-Invasiva Diagnostic Techniques in Deep Vein Thrombosis.- Evaluationof the Bleeding Effects of Antithrombotic Drugs.- List of Participants.- List of Sponsors.