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Negative Co-Receptors and Ligands
Langbeschreibung
Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or downmodulation to avoid excessive damage to the host tissue. For both branches of the adaptive immune system, regulatory molecules i.e. coreceptors and ligands have been identified that control the signaling cascades initiated by engagement of the T cell and B cell antigen receptors. This book describes biological functions as well as molecular mechanisms of these molecules.
Hauptbeschreibung
Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates.
Inhaltsverzeichnis
Preface.- TIM-3 and its regulatory role in immune responses.- The role of PD-1 in regulating T cell immunity.- The role of IL-10 in regulating immunity to persistent viral infections. -Inhibitory Ly49 receptors on mouse Natural Killer cells.-Immunoregulatory roles for Fc receptor-like molecules.- Fcgamma Rs in health and disease.- TGF-beta function in immune suppression.- Subject index
ISBN-13:
9783642195440
Veröffentl:
2011
Erscheinungsdatum:
08.04.2011
Seiten:
160
Autor:
Tasuku Honjo
Gewicht:
412 g
Format:
241x160x14 mm
Serie:
350, Current Topics in Microbiology and Immunology
Sprache:
Englisch
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