Tissue Restoration Through Regenerative Biology and Medicine

The cost of tissue damage due to degenerative disease and injury is enormous in terms of health care costs, lost economic productivity, diminished quality of life and premature death. Advances in cell, developmental and molecular biology, and the discovery of regeneration-competent cells in many non-regenerating mammalian tissues, have given impetus to systematic investigations that will enable us to regenerate these tissues by cell transplantation or the pharmaceutical induction of regeneration from the body's own tissues. A significant avenue of research is the identification of the soluble and insoluble signals and their transduction pathways that govern the proliferation and differentiation of regeneration-competent cells, and the signals that inhibit their activity after injury. The most direct experimental strategy to identify the chemical and physical signals that promote regeneration and the factors that inhibit it is to make genomic and proteomic comparisons, using bioinformatic analyses, of regeneration-competent vs regeneration-deficient tissues. Once identified, the molecular promoters of regeneration can be used in clinical treatments.

1 Introduction.- 1.1 The Biology of Regeneration.- 1.2 Regeneration of Ectodermal Derivatives.- 1.3 Regeneration of Endodermal Derivatives.- 1.4 Regeneration of Mesodermal Derivatives.- 1.5 Developmental Potential of Adult Stem Cells.- Regenerative Medicine.- 2.1 Cell Transplants.- 2.2 Chemical Induction of Regeneration In Vivo.- 3 Perspectives.- References.