Asymmetric Synthesis II

Eine Gruppe international renommierter Autoren vermittelt die neuesten Forschungsergebnisse im Bereich der asymmetrischen Synthese. Studenten höherer Semester und Forscher finden in diesem Lehrbuch eine einzigartige Themensammlung, u. a. auch zu Anwendungen in der Industrie.

CATALYTIC ENANTIOSELECTIVE ALKYLATION OF PROCHIRAL KETONE ENOLATES Background Strategy and Results Asymmetric Allylic Alkylation in Total Synthesis Conclusions POINT-TO-PLANAR CHIRALITY TRANSFER IN TOTAL SYNTHESIS: SCALABLE AND PROGRAMMABLE SYNTHESIS OF HAOUAMINE A AND ITS ATROPISOMER Introduction Synthetic Strategy Featuring Point-to-Planar Chirality Transfer Programmable Synthesis of Haouamine A and Its Atropisomer TETHERED AMINOHYDROXYLATION Introduction and Background Tethered Aminohydroxylation Amide-Based ReoxidantsEvidence for the Mechanism of the TA ReactionApplications in Organic Synthesis Conclusion and Future Work ORGANOCATALYZED TRANSFORMATIONS OF A, B-UNSATURATED CARBONYL COMPOUNDS THROUGH IMINIUM ION INTERMEDIATES THE RENAISSANCE OF SILICON-STEREOGENIC SILANES: A PERSONAL ACCOUNT Background Results Conclusion ASYMMETRIC DIENAMINE ACTIVATION IntroductionHistoric Background Results Conclusion ASYMMETRIC BRØNSTED ACID CATALYSIS Introduction and Background Strategy Results Summary QUATERNARY STEREOGENIC CENTERS BY ENANTIOSELECTIVE B-CARBON ELIMINATIONS FROM TERT-CYCLOBUTANOLS Background Objective: Enantioselective Formation of Quaternary Stereogenic Centers in Combination with Reactive Alkyl-RhodiumIntermediates Selective Generation of the Alkyl-Rhodium Species and Its Downstream Reactivities TOTAL SYNTHESIS OF OSELTAMIVIR AND ABT-341 USING ONE-POT TECHNOLOGY Introduction Results Conclusions ENANTIOSELECTIVE ANNULATIONS WITH CHIRAL N-MESITYL N-HETEROCYCLIC CARBENES Introduction Catalytic Generation of Chiral Enolate Equivalents Catalytic Generation of Homoenolate Equivalents Enantioselective Cascade Reactions Catalyzed by Chiral N-Heterocyclic Carbenes Catalytic Annulations via a, ß-Unsaturated Acyl Azoliums Conclusions ASYMMETRIC COUNTERANION-DIRECTED CATALYSIS (ACDC) Concept Application of ACDC to Organocatalysis Application of ACDC to Transition Metal Catalysis Application of ACDC to Lewis Acid Catalysis ENANTIOSELECTIVE ORGANO-SOMO CATALYSIS: A NOVEL ACTIVATION MODE FOR ASYMMETRIC SYNTHESIS Background Objective Results ENANTIOSELECTIVE PASSERINI REACTION Introduction Background Results Conclusion and Perspective RAPID ENANTIOMERIC EXCESS DETERMINATION ASYMMETRIC CATALYSIS OF REVERSIBLE REACTIONS Thermochemistry of Asymmetric Catalyses Close to the Equilibrium Kinetic Modeling of a Reversible Asymmetric Catalytic Reaction Case Study: a Reversible Asymmetric Organocatalytic Reaction Conclusions EXPLOITING FLUORINE CONFORMATIONAL EFFECTS IN ORGANOCATALYST DESIGN: THE FLUORINE?IMINIUM ION GAUCHE EFFECT DUTCH RESOLUTION CONSTRUCTION OF ANTI-ME-OH VICINAL RELATIONSHIPS IN POLYKETIDES Introduction Marshall - Tamaru Reaction Conclusions PHOTOSWITCHABLE GENERAL BASE CATALYSTS Introduction and Background Strategy and Results Outlook ASYMMETRIC HALONIUM ADDITION TO OLEFINS Introduction Intramolecular Lactonizations, Etherifications, and Aminations Polyene Cyclizations Intermolecular Additions to Alkenes Conclusion CATALYTIC ASYMMETRIC GOSTELI - CLAISEN REARRANGEMENT (CAGC) BIOMIMETIC TOTAL SYNTHESIS OF THE PENIFULVIN FAMILY Introduction The Penifulvin Family: Isolation and Biogenetic Origin Total Syntheses of Penifulvins A, B, and C Summary CATALYST-CONTROLLED 1,3-POLYOL SYNTHESES ENANTIOSELECTIVE CARBONYL ALLYLATION AND CROTYLATION FROM THE ALCOHOL OXIDATION LEVEL VIA C?C BOND FORMING TRANSFER HYDROGENATION Introduction and Background StrategyResults STEREOSELECTIVE SYNTHESIS WITH HYPERVALENT IODINE REAGENTS ASYMMETRIC GOLD-CATALYZED REACTIONS Introduction Diphosphine-Gold Complexes in Enantioselective Catalysis Monophosphine-Gold Complexes in Enantioselective Catalysis ASYMMETRIC CATALYSIS IN THE TOTAL SYNTHESIS OF LIPIDS AND POLYKETIDES BackgroundTuberculostearic Acid: One Isolated Methyl Group Ant Pheromones: Vicinal Methyl Branches Deoxypropionates: 1,3-Methyl ArraysMembrane-Spanning Lipids: