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Epigenetics for Drug Discovery
Langbeschreibung
Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington's disease and from inflammation to sickle cell anaemia.
Inhaltsverzeichnis
Epigenetics - What it is and Why it Matters; Enzyme and Protein Families that Regulate Histone Modifications and Crosstalk; Epigenetics and Disease; Targeting DNA Methylation; Targeting Histone Acetylation; Targeting Histone Lysine Methyltransferases in Cancer; Targeting Non-Acetylation Histone Erasers; Progress in Targeting Epigenetic Readers; Who will Bebefit from Epigenetic Drugs; Dosing - When Less Is More; Histone Methyltransferase Activity Assays; Safety Considerations for Epigenetic Mechanisms as Drug Targets: Are Existing Toxicology Studies Fit for Purpose?;
ISBN-13:
9781849738828
Veröffentl:
2015
Erscheinungsdatum:
20.11.2015
Seiten:
336
Autor:
Nessa Carey
Gewicht:
635 g
Format:
236x163x23 mm
Sprache:
Englisch
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