IGF and Nutrition in Health and Disease

A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.

Includes supplementary material: sn.pub/extras

I . OverviewOverview and Molecular Aspects of the Insulin-Like Growth Factor SystemMartin L. Adamo, Lai Wang, Lisa Heron, Dalit Ben-Yosef, Hong Zhao, and Derek Le RoithII. IGF and Nutritional StatusRegulation of Insulin-Like Growth Factor-I by NutritionJean-Paul Thissen, Véronique Beauloye, Jean-Marie Ketelslegers, and Louis E. UnderwoodNutrition and IGF Proteins in Chronic Malnutrition and Critical IllnessPei-Ra Ling and Bruce R. BistrianThe Insulin-Like Growth Factors and Assessment of Nutritional StatusM. Sue HoustonIII. Growth and DevelopmentRegulation of Growth and the Insulin Growth Factor System by ZincRuth S. MacDonaldThe Role of the Insulin-Like Growth Factor System in Pre- and Postnatal Growth, Development, and TumorigenesisCharles T. Roberts, Jr.The Insulin-Like Growth Factor Axis in the Fetus and NeonateCynthia L. Blanco and Robert J. Ferry, Jr.Nutrition and the IGF System in ReproductionFrank A. Simmen, Inseok Kwak, Jason L. Blum, and Rosalia C. M. SimmenThe Insulin Growth Factor System and Nutrition in Adulthood and AgingMoira S. Lewitt and Kerstin HallIV. IGF and Organ SystemsNutrition and Insulin Growth Factor-I in Relation to Bone Health and DiseaseJean-Philippe Bonjour, Patrick Ammann, Thierry Chevalley, and René RizzoliEffect of Insulin-Like Growth Factor Proteins on Skeletal Muscle Protein Metabolism During Normal and Catabolic ConditionsCharles H. Lang and Robert A. FrostInsulin-Like Growth Factors and Nervous System DisordersGary Meyer, Aparna Bole, and Eva L. FeldmanThe Kidney and the Insulin-Like Growth Factor System in Health and DiseaseRalph Rabkin, Steven S. Guest, and Franz SchaeferV. IGF in Disease StatesThe IGF and IGFBP System in InsulinResistance and Diabetes MellitusKerstin Brismar and Moira S. LewittInsulin-Like Growth Factors in Relation to Gastrointestinal Diseases and Parenteral NutritionDenise M. NeyImpact of Critical Illness on the Growth Hormone/Insulin Growth Factor System in Relation to Other Endocrine ResponsesGreta Van den BergheMechanisms of Cardiac Hypertrophy and the Development of Heart Failure: Role of Insulin-Like Growth Factor-I and Angiotensin-IIPatrice Delafontaine, Marijke Brink, and Yao-Hua SongRoles of the Insulin-Like Growth Factor System and Nutrition in CancerClaire M. Perks and Jeffrey M. P. HollyAppendix AAppendix BIndex