IGF and Nutrition in Health and Disease

From birth to death, the insulin-like growth factors (IGF) -a system of proteins, binding proteins, and cell receptors that are widely expressed in all tissues-plays critical roles in metabolism, normal growth and development, and numerous acute and chronic diseases. The IGF system is fundamentally related to growth hormone and insulin, but also nutritional state. In IGF and Nutrition in Health and Disease, leading researchers and physicians from diverse disciplines comprehensively review for the first time how specific nutrients or adverse nutritional states impact gene expression, circulating concentrations, and bioactivity of the IGF proteins. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, and examine the interactions between IGF and nutritional status from the molecular to the population levels. Their discussion of the essential interrelationships between IGF and nutrition, including specific nutrients, in physical development across the life span illuminates the balance between normal growth and development and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.Comprehensive and authoritative, IGF and Nutrition in Health and Disease is a benchmark review of nutrition and the IGF system in human health and disease, providing a clear understanding of the critical importance of the IGF system and nutritional state to human growth, metabolism, disease development, and therapy.

I Overview.- 1 Overview and Molecular Aspects of the Insulin-Like Growth Factor System.- II IGF and Nutritional Status.- 2 Regulation of Insulin-Like Growth Factor-I by Nutrition.- 3 Nutrition and IGF Proteins in Chronic Malnutrition and Critical Illness.- 4 The Insulin-Like Growth Factors and Assessment of Nutritional Status.- III Growth and Development.- 5 Regulation of Growth and the Insulin Growth Factor System by Zinc.- 6 The Role of the Insulin-Like Growth Factor System in Pre- and Postnatal Growth, Development, and Tumorigenesis.- 7 The Insulin-Like Growth Factor Axis in the Fetus and Neonate.- 8 Nutrition and the IGF System in Reproduction.- 9 The Insulin Growth Factor System and Nutrition in Adulthood and Aging.- IV IGF and Organ Systems.- 10 Nutrition and Insulin Growth Factor-I in Relation to Bone Health and Disease.- 11 Effect of Insulin-Like Growth Factor Proteins on Skeletal Muscle Protein Metabolism During Normal and Catabolic Conditions.- 12 Insulin-Like Growth Factors and Nervous System Disorders.- 13 The Kidney and the Insulin-Like Growth Factor System in Health and Disease.- V IGF in Disease States.- 14 The IGF and IGFBP System in Insulin Resistance and Diabetes Mellitus.- 15 Insulin-Like Growth Factors in Relation to Gastrointestinal Diseases and Parenteral Nutrition.- 16 Impact of Critical Illness on the Growth Hormone/Insulin Growth Factor System in Relation to Other Endocrine Responses.- 17 Mechanisms of Cardiac Hypertrophy and the Development of Heart Failure: Role of Insulin-Like Growth Factor-I and Angiotensin-II.- 18 Roles of the Insulin-Like Growth Factor System and Nutrition in Cancer.- Appendix A.- Appendix B.