Intraoperative Irradiation

n Intraoperative Irradiation: Techniques and Results, a team of international radiation oncologists, surgeons, and scientists comprehensively review the techniques, indications, and results of using intraoperative electrons (IOERT) and high-dose rate brachytherapy (HDR-IORT). State-of-the-art topics range from methods and techniques of treatment and issues of normal tissue/organ tolerance to IORT, to techniques and results by disease-site, as well as future possibilities. The disease-site chapters cover every body part for which the potential merit of IORT has been demonstrated, providing a balanced presentation by a radiation oncologist and a surgeon of disease-specific treatment factors. The diseases range from GI cancers to CNS and breast malignancies, and the treatment outcomes discussed include data on disease control (local and distant), on survival (disease-free and overall), and on treatment tolerance.International in authorship and comprehensive in scope, Intraoperative Irradiation: Techniques and Results offers a cutting-edge resource and reference for surgeons, radiation oncologists, physicists, anesthesiologists, medical oncologists, and all others providing IORT and HDR-IORT procedures and cancer care today.

I. General Rationale and Historical Perspective.- 1 General Rationale and Historical Perspective of Intraoperative Irradiation.- 2 Biology of Large Dose per Fraction Radiation Therapy.- II. Methods and Techniques of Treatment.- 3 Physical Aspects of Intraoperative Electron-Beam Irradiation.- 4 IOERT Treatment Factors: Technique, Equipment.- 5 Physics of Intraoperative High-Dose-Rate Brachytherapy.- 6 High-Dose-Rate Intraoperative Irradiation (HDR-IORT): Technical Factors.- 7 Intraoperative Irradiation with Electron-Beam or High-Dose-Rate Brachytherapy: Methodological Comparisons.- III. Normal Tissue Tolerance-IORT.- 8 Normal Tissue Tolerance to Intraoperative Irradiation: The National Cancer Institute Experimental Studies.- 9 Studies at Colorado State University of Normal Tissue Tolerance of Beagles to IOERT, EBRT, or a Combination.- 10 Peripheral Nerve Tolerance: Experimental and Clinical.- IV. Results of IORT with or Without EBRT by Disease Site.- 11 Gastric IORT With or Without EBRT.- 12 IORT in Pancreatic Carcinoma.- 13 Biliary Tract IORT: Bile Duct and Gallbladder.- 14 Primary Colorectal EBRT and IOERT.- 15 Recurrent Colorectal: EBRT With or Without IOERT or HDR-IORT.- 16 HDR-IORT for Colorectal Cancer: Clinical Experience.- 17 Radiation Ablation of Liver Metastases: HDR-IORT With or Without EBRT.- 18 Electron or Orthovoltage IORT for Retroperitoneal Sarcomas.- 19 HDR-IORT for Retroperitoneal Sarcomas.- 20 Extremity and Trunk Soft Tissue Sarcomas: EBRT With or Without IORT.- 21 IORT for Bone Sarcomas.- 22 Locally Advanced Primary and Recurrent Gynecologic Malignancies: EBRT With or Without IOERT or HDR-IORT.- 23 Genitourinary IORT.- 24 Lung Cancer: EBRT With or Without IORT.- 25 Pediatric Malignancies: IORT Alone or With EBRT.- 26 IORT for Head and Neck Cancer.-27 IORT for CNS Tumors.- 28 IORT for Breast Cancer.- V. Conclusions and Future Possiblities.- 29 Conclusions and Future Possiblities-IORT.