Brain Tumor Immunotherapy

It is now clear from basic research and clinical trials that immunotherapy for brain tumors is feasible, can evoke relevant biologic responses, and can yield important insights into human biology. In Brain Tumor Immunotherapy, an authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying tumor immunotherapy. Introductory material brings the reader up-to-date on the biological principles of brain tumor immunotherapy, along with the neuropathology, molecular pathogenesis, epidemiology, and the relevant current therapies.Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics.

Part I. Introduction to the Disease. Neuropathology and Molecular Pathogenesis of Primary Brain Tumors, Paul S. Mischel and Harry V. Vinters. Epidemiology of Primary Brain Tumors, Susan Preston-Martin, Faith Davis, and Roberta McKean-Cowdin. Current Therapy for Primary Brain Tumors, John M. Duff, Pierre-Yves Dietrich, and Nicolas de Tribolet. Part II. Introduction to Immunotherapy of Brain Tumors. Immunostimulation and Immunomodulation of Brain Tumors, Victor C. K. Tse and Frances K. Conley. Biological Principles of Brain Tumor Immunotherapy, Amy B. Heimberger, Darell D. Bigner, and John H. Sampson. Part III. Adoptive Cellular Immunotherapy of Brain Tumors. Systemic T-Cell Immunotherapy for Brain Tumors, Gregory E. Plautz and Suyu Shu. Cytotoxic T-Lymphocytes Reactive to Patient Major Histocompatibility Complex Proteins for Therapy of Brain Tumors, Carol A. Kruse and David Rubinstein. Autologous Vaccine and Adoptive Cellular Immunotherapy as Treatment for Brain Tumors, Gary W. Wood and Frank P. Holladay. Part IV. Antibody-Mediated Immunotherapy of Brain Tumors. Anti-Idiotype Immunotherapy Strategies for Brain Tumors, Nai-Kong V. Cheung. Radiolabeled Antibodies for Therapy of Brain Tumors, Carol J. Wikstrand, Michael R. Zalutsky, and Darell D. Bigner. Immunotoxin Therapy of Brain Tumors, Walter A. Hall. Antibodies to Adhesion Molecules for Immunotherapy of Brain Tumors, S. Ather Enam. Part V. Tumor Vaccines and Other Strategies. Cytokine-Based Immuno-Gene Therapy for Brain Tumors, Roberta P. Glick, Terry Lichtor, and Edward P. Cohen. Downregulation of Transforming Growth Factor b as Therapeutic Approach for Brain Tumors, Habib Fakhrai, Svetlana Gramatikova, and Rohangiz Safaei. Dendritic Cell Immunotherapy for Brain Tumors, Stéphane Vandenabeele, Linda M. Liau, andDavid Ashley. Death Ligand/Death Receptor-Mediated Apoptosis for Treatment of Brain Tumors, Wilfried Roth and Michael Weller. Combining Radiation Therapy with Immunotherapy for Treatment of Brain Tumors,William H. McBride. Index.