Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury

This volume contains the proceedings of the First International Conference on Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury held in Detroit, Michigan on October 11-14, 1989. The program consisted of 83 oral and 29 poster presentations, 74 of which are included in these proceedings. The major sponsors of the conference were the Armed Forces Radiobiology Research Institute, located in Bethesda, Maryland, the Radiation Oncology Research and Development Center of the Gershenson Radiation Oncology Center, Harper Hospital in Detroit, Michigan, and Schering AG of West Germany. Eighteen other organizations provided additional support. The conference was unique in its attempt to link the eicosanoid and lipid researchers in the radiobiology and cancer disciplines. The diverse roles that eicosanoids and other bioactive lipids play in these biological phenomena including the participation of lipid oxidation in conversion of procarcinogens, positive and negative modulation of tumor growth, immunomodulation, tissue injury, and yet protection and enhancement of cancer therapy, necessitated scientific interaction to sort out and understand these complex and sometimes contradictory observations. The success of this effort is reflected not only through these proceedings, but also through the decision to continue the conference series with a second meeting to be held in Berlin between September 17-21, 1991.

Phospholipid turnover oxygenases and fatty acid metabolism.- Radiation and Chemical Carcinogenesis.- Lipid Peroxidation, Eicosanoid biosynthesis, and Radiation induced tissue injury.- Antioxidant Enzyme Action.- Dietary lipid actions.- Immunomodulation.- Receptor Modulation of lipid Metabolism.- Eicosanoid Modulation of receptor Expression.- Tumor Growth invasion and differentiation.- Effects of Eicosanoid analogs on tumor growth and Metastasis.- Paf & Ether lipids - Role in radiation injury and tumor growth.- Clinical Implications.