Necrotic Cell Death

This essential volume in the Cell Death in Biology and Diseases series presents comprehensive coverage of necrosis from recognized experts at leading academic and medical institutions around the world, thus keeping pace with the emerging research interest in necrosis. Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at the several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death.  As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis.

Necrotic cell death at a glance: concept, mechanisms and biological functions.- Necroptosis: Alternative death modality under death receptors.- RIP1 and RIP3 in necrotic cell death.- PARP-mediated necrotic cell death.- Autophagic cell death, true or false?.- Oxidative stress and necrotic cell death.- Necrosis and DNA damage.- Lysosomes in necrotic cell death.- Necrotic cell death in development.- Necrotic cell death  in immunity.- Necrotic cell death in inflammation.- Necrotic cell death and cancer.- Necrotic cell death in ischemia reperfusion injury.- Necrostatin, a necrosis inhibitor as a therapeutic agent.- Necrotic cell death in model organisms (C. elegan).- Methodology in studying necrotic cell death.¿