Carotenoids and Vitamin A in Translational Medicine

Vitamin A (retinol) is an essential dietary compound with myriad metabolic and regulatory functions. More than 600 carotenoids have been identified in plants, algae, fungi, and bacteria, and around 50 carotenoids-includingcarotene-can be converted into vitamin. This volume reviews the medical use of carotenoids and vitamin A in cancer; diseases of the skin, eye, ear, and lung; and inflammatory bowel and metabolic diseases. It also discusses the analytics of carotenoids and the supply of carotenoids and vitamin A in developing countries. The book evaluates basic research, epidemiological studies, and clinical trials in the field.

Carotenoids and Vitamin A in Metabolic Diseases.Hepatic Retinoid Metabolism What Is Known and What Is Not. Metabolism of Vitamin A in White Adipose Tissue and Obesity. Retinoids in the Treatment of Psoriasis. Age-Related Macular Degeneration and Carotenoids. Lutein, Zeaxanthin, and Vision across the Life Span. Assuring Vitamin A Adequacy to Prevent Eye and Ear Disorders. Disturbed Accumulation and Abnormal Distribution of Macular Pigment in Retinal Disorders. Retinol and Otitis Media. Carotenoids and Vitamin A in Cancer. Carotenoids and Mutagenesis. Carotenoids and Vitamin A in Lung Cancer Prevention. Is the Effect of Carotene on Prostate Cancer Cells Dependent on Their Androgen Sensitivity? Carotenoid Intake and Supplementation in Cancer: Pro and Con. Carotenoids and Vitamin A in Other Diseases. Vitamin A in Lung Development and Function. Vitamin A and Carotenoids in Lung Diseases. Chemopreventive Effects of Astaxanthin on Inflammatory Bowel Disease and Inflammation-Related Colon Carcinogenesis. Meeting Dietary Supply of Vitamin A and Carotenoids. Carotenoids in Laboratory Medicine. Supply of Vitamin A in Developing Countries. Vitamin A Intakes Are Below Recommendations in a Significant Proportion of the Population in the Western World. Critical Appraisal of Vitamin A Supplementation Program in India. Consequences of Common Genetic Variations on Carotene Cleavage for Vitamin A Supply. Index.