An Introduction to Biomaterials

The second edition of this popular text includes nine new chapters that provide a comprehensive and up-to-date educational framework for biomaterials education. A new chapter on the biology of wound healing sets the stage for the basic requirements of standardized biomaterials testing and explains the reactions between biomaterials and the living system into which it is implanted. The book explains in vitro and in vivo testing paradigms and provides numerous examples in the chapters on experimental design, laboratory assays, and animal models. Emphasizing the importance of the regulatory process, it describes how innovation in the biomaterials process relates to patentability and inventorship.

Consensus Definitions, Fundamental Concepts, and a Standardized Approach to Applied Biomaterials Sciences. Biology, Biomechanics, Biomaterial Interactions: Wound Healing Biology. Cutaneous Wound Pathobiology: Raison d'etre for Tissue Engineering. Osseous Wound Healing. Biology, Biomechanics, Biomaterial Interactions: Cellular Mechanics. Cell and Tissue Mechanobiology. Biology, Biomechanics, Biomaterial Interactions: Materials-Host Interactions. Cell-Material Interactions: Fundamental Design Issues for Tissue Engineering and Clinical Considerations. Host Response to Biomaterials. Protein Adsorption at the Biomaterial-Tissue Interface. Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Standardized Materials Testing. In Vitro Testing of Biomaterials. Assessment of Biomaterials: Standardized In Vivo Testing. Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Statistics. Basic Principles of Statistics: Considerations for Biomaterials Engineers. Therapy Development, Animal Testing, and Regulatory Issues. Fundamentals of Patenting for the Biomaterials Scientist. Biomaterials Compositions. Proteins and Amino Acid-Derived Polymers. Three-Dimensional Fibrin Constructs in Tissue Engineering. Biomedical Polyurethanes. Polymers Derived from l-Tyrosine. Poly(propylene Fumarate). Complex Polysaccharides: Chitosan and Alginate. Collagen: A Natural Biomaterial for Tissue Engineering. Polyphosphazenes. Biologically Active Glasses. Silk-Based Biomaterials: Biology, Properties, and Clinical Applications. Calcium-Based Bioceramics: Biology, Properties, and Clinical Applications. Biomaterials Applications. Tissue Engineering of Skin. Polymeric Biomaterials for Drug and Nucleic Acid Delivery. Orthopedic Prostheses and Joint Implants. Bone and Biomaterials. Functional Regenerat