Methods for Preclinical Research in Addiction

This volume presents a wide array of animal models that are used in the study of the individual and environmental factors involved in the development of addiction, the consequences of chronic drug exposure, and recently developed behavioral and biological procedures for the treatment of addictive disorders. The chapters in this book are organized into three sections that cover the aforementioned aspects in relation to different drugs of abuse and pathological gambling. The first section of the book focuses on the individual variables that affect vulnerability to addiction to nicotine, alcohol, cocaine, psychostimulants, and gambling. Section Two looks at the environmental variables that contribute to the vulnerability to addiction. Section Three explores the consequences of chronic drug consumption and new approaches to the treatment of addiction. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successfulresults in your laboratory.Cutting-edge and comprehensive, Methods for Preclinical Research in Addiction is a valuable resource that helps researchers and scientists understand the neurobiological mechanisms that underlie the influence of individual and environmental variables on the risk for addiction, and assists them in developing new behavioral and pharmacological strategies to prevent and treat addictive disorders.

Includes cutting-edge methods and protocols

Influence of Sex on the Effects of Nicotine and Other Drugs of Abuse on Intracranial Self-Stimulation.- Animal Models of Adolescent Binge Drinking.- Prepulse Inhibition and Vulnerability to Cocaine Addiction.- Modulation of the Effects of Alcohol, Cannabinoids, and Psychostimulants by the Novelty-Seeking Trait.- Cognitive Biases Associated with Vulnerability to the Development of Pathological Gambling.- Extended Drug Access and Escalation of Drug-Self Administration.- Preclinical Models of Relapse to Psychostimulants Induced by Environmental Stimuli.- Influence of Social Defeat Stress on the Rewarding Effects of Drugs of Abuse.- Environmental Enrichment and the Effects on Drug Abuse Vulnerability: The Last Ten Years.- Investigation of Individual Differences in Stress Susceptibility and Drug-Seeking in an Animal Model of SUD/PTSD Comorbidity.- Working and Reference Memory Impairments Induced by Passive Chronic Cocaine Administration in Mice.- Transcranial Direct Current Stimulation to Reduce Addiction-Related Behaviors in Mice.- Manipulating Reconsolidation to Erase Drug Memory.