Molecular Biology of B Cells

Molecular Biology of B Cells, Third Edition is a comprehensive reference to how B cells are generated, selected, activated, and engaged in antibody production. These developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Third Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on B cell development and function, the use of therapeutic antibodies in cancer and infectious disease, therapeutic targeting of B cells for clinical application, new developments in lymphoma biology. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Third Edition is the definitive resource, vital for researchers across molecular biology, immunology, and genetics.

1. The Structure and Regulation of the Immunoglobulin LociJoseph S. Lucas, Cornelis Murre, Ann J. Feeney and Roy Riblet2. The Mechanism, Regulation and Evolution of V(D)J RecombinationDavid G. Schatz, Yiwen Zhang, Jianxiong Xiao, Shan Zha, Yu Zhang and Frederick W. Alt3. The Origin of V(D)J DiversificationEllen Hsu and Susanna M. Lewis4. The Variable Lymphocyte Receptor B System of the Jawless VertebratesThomas Boehm, Max D. Cooper, Masayuki Hirano, Sabyasachi Das, Ryo Morimoto and Jonathan P. Rast5. Structure and Signalling Function of the B-Cell Antigen Receptor and Its CoreceptorsMichael Reth, Kathrin Klasener, Lars Nitschke and Michael R. Gold6. Fc ReceptorsJeffrey V. Ravetch and Stylianos Bournazos7. Transcriptional Regulation of Early B-Cell DevelopmentAshley P. Ng, Rhiannon Morris and Stephen L. Nutt8. Relationship between B-Cell Populations, Development and Function of B-Cell SubsetsEva Piano Mortari and Rita Carsetti9. B-Cell Development to Immunity and ToleranceFritz Melchers, Mir-Farzin Mashreghi and Peter K. Jani10. The Role of the BAFF and Lymphotoxin Pathways in B Cell BiologyFabienne Mackay and Jennifer L. Gommerman11. Mechanism and Regulation of Immunoglobulin Class Switch RecombinationFei-Long Meng, Lekha Nair, Keith C. Fernandez, Uttiya Basu and Jayanta Chaudhuri12. Somatic HypermutationJana Ridani, Philip Barbulescu, Alberto Martin and Javier M. Di Noia13. Molecular Mechanism of Activation-Induced Cytidine DeaminaseNasim A. Begum, Maki Kobayashi, Hitoshi Nagaoka and Tasuku Honjo14. Molecular Pathogenesis of B-Cell LymphomasLaura Pasqualucci, Pantaleo De Simone and Riccardo Dalla-Favera15. Human Immunodeficiencies Caused by Inborn Errors of B-Cell Development or FunctionStuart G. Tangye, Jean-Laurent Casanova and Cindy S. Ma16. Memory B Cells and Plasma CellsMairi Anne McGrath, Florian Weisel, Andreas Radbruch and Mark Shlomchik17. Homoeostatic Versus Pathogenic Autoantibodies: Origin, Structure and Effector FunctionsYemil Atisha-Fregoso, Rita Pozovskiy, Shabirul Haque, Manami Watanabe, Yong-Rui Zou and Betty Diamond18. Anti-Tumour Necrosis Factor and New Paradigms for Therapies Using AntibodiesSergei A. Nedospasov, Marina S. Drutskaya and Andrey A. Kruglov19. Therapeutic Targeting of B Cells and Plasma Cells with a Focus on Multiple Sclerosis and Other Autoimmune ConditionsAndreia C. Lino and Thomas Dorner20. IMGT Immunoglobulin RepertoireAnalysis and Antibody Humanization Marie-Paule Lefranc21. Mucosal Immunity to Bacteria and Immunoglobulin A SynthesisAndrew J. Macpherson, Tim Rollenkse, Lucia M. Kato and Sidonia Fagarasan22. B-Cell MetabolismJulia Jellusova