Prostate Cancer: New Horizons in Research and Treatment

In recent years the pace of research in prostate cancer has increased dramatically. Creative ideas in combination with new and emerging technologies have led to an explosion of discovery. These types of advances in prostate cancer research presage an era of new treatment strategies based on an understanding of the cellular and molecular mechanisms of disease. In creating this book, we aimed to cover a broad "bench to bedside" research spectrum ranging from: genetic, molecular and cellular analyses to epidemiological studies, refinements in local treatment strategies and new biologically based non-hormonal treatments for systemic disease. Researchers and clinicians will find in this book a group of timely and clinically relevant chapters on prostate cancer research and treatment.

Pathology of prostate cancer.- Prostate cancer susceptibility genes: Many studies, many results, no answers.- Molecular profiling in prostate cancer.- Chromosomal deletions and tumor suppressor genes in prostate cancer.- Role of eicosanoids in prostate cancer progression.- Contribution of the androgen receptor to prostate cancer predisposition and progression.- Regulation of apoptosis in prostate cancer.- On the role of cell surface carbohydrates and their binding proteins (lectins) in tumor metastasis.- Metastasis suppression in prostate cancer.- The urokinase-type plasminogen activator system in prostate cancer metastasis.- Angiogenesis in prostate cancer: Biology and therapeutic opportunities.- Integrins and prostate cancer metastases.- Prostate carcinoma skeletal metastases: Cross-talk between tumor and bone.- Signal transduction targets in androgen-independent prostate cancer.- The diet, prostate inflammation, and the development of prostate cancer.- Prostate cancer diagnosis, staging and survival.- Surgery for prostate cancer: Rationale, technique and outcomes.- The future of cancer imaging.- Antisense therapy: Current status in prostate cancer and other malignancies.- Antiangiogenesis therapeutic strategies in prostate cancer.- Chemoprevention of prostate cancer.- Prostate brachytherapy.- Fast neutron irradiation for prostate cancer.- Prostate cancer gene therapy: Past experiences and future promise.- Vitamin D-related therapies in prostate cancer.- Osteoporosis and other adverse body composition changes during androgen deprivation therapy for prostate cancer.