Ribosomes

Dr. Spirin is a world authority on ribosomes and has published two earlier books in this area in English. This text is for advanced undergraduates and beginning graduate students and will cover the structure, function, and biosynthesis of ribosomes. Ribosomes are important in protein synthesis, which is currently a hot topic in many different areas of research.

Historical and Fundamental Introduction.- Protein Biosynthesis.- Messenger RNA and the Genetic Code.- Transfer RNA and Aminoacyl-tRNA Synthetases.- Ribosomes and Translation.- Structure of the Ribosome.- Morphology of the Ribosome.- Ribosomal RNA.- Ribosomal Proteins.- Mutual Arrangement of Ribosomal RNA and Proteins (Quaternary Structure).- Function of the Ribosome.- Functional Activities and Functional Sites of the Ribosome.- Elongation Cycle, Step I: Aminoacyl-tRNA Binding.- Elongation Cycle, Step II: Transpeptidation (Peptide Bond Formation).- Elongation Cycle, Step III: Translocation.- Elongation Rates and its Modulation.- Termination of Translation.- Initiation of Translation.- Translational Control in Prokaryotes.- Translational Control in Eukaryotes.- Cotranslational Folding and Transmembrane Transport of Proteins.- Conclusion: General Principles of Ribosome Structure and Function.