Oxford Textbook of Oncology

Written and edited by internationally recognised leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer.Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and aftertreatment.A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care.The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Section 1: Hallmarks of Cancer; 1 Douglas Hanahan and Robert A. Weinberg: The hallmarks of cancer; 2 Shujuan Liu and Ahmed Ashour Ahmed: Growth factors and uncontrolled proliferation; 3 Stefan Knapp: Cell signalling pathways; 4 Simon Carr and Nicholas La Thangue: Cell cycle control; 5 Amanda S. Coutts, Sandra Maniam, and Nicholas La Thangue: Cancer cell death; 6 Yull E. Arriaga and Arthur E. Frankel: Angiogenesis; 7 Andrew P. Mazar, Andrey Ugolkov, Jack Henkin, Richard Ahn, and Thomas V. O'Halloran: Invasion and metastases; 8 Sir Walter Bodmer and Jenny Wilding: Genetic instability; 9 E. Dikomey, K. Borgmann, M. Kriegs, W. Mansour, C. Petersen, and T. Rieckmann: DNA repair after oncological therapy; 10 Andreas Trumpp: Biology of cancer stem cells; 11 Richard D Kennedy, Manuel Salto-Tellez, D. Paul Harkin, and Patrick G Johnston: Biomarker identification and clinical validation; 12 Campbell SD Roxburgh and Donald C McMillan: Cancer, immunity, and inflammation; 13 Cameron Snell, Kevin C Gatter, Adrian L Harris, Francesco Pezzella: Cancer and metabolism; Section 2: Etiology and Epidemiology of Cancer; 14 Jonathan Samet: Smoking and cancer; 15 Chris Boshoff: Viruses; 16 Paula A. Oliveira: Chemical carcinogens; 17 Klaus Trott: Radiation; 18 Ellen Kampman and Franzel van Duijnhoven: Body fatness, physical activity, diet, and other lifestyle factors; Section 3: Principles of Oncology; 19 PG Boelens, CBM van den Broek, and CJH van de Velde: Practice points for surgical oncology; 20 Annekatrin Singer, Stephanie E. Combs, Jurgen Debus, and Michael Baumann: Practice points for radiation oncology; 21 David Kerr, Daniel Haller, and Jaap Verweij: Principles of chemotherapy; 22 David N Church, Rachel S Midgley, and David J Kerr: Delivery of multidisciplinary cancer care; 23 Michael Ong and Udai Banerji: Principles of clinical pharmacology: Introduction to pharmacokinetics and pharmacodynamics; 24 Dan Sargeant and Qian Shi: Design and analysis of clinical trials; 25 Eric A. Singer: Medical ethics in oncology; 26 Jeffrey Peppercorn: Health economic assessment of cancer therapy; Section 4: Population Health; 27 Masoud Samiei: Cancer control: The role of national plans; 28 Sarah Goltz and Julian Lob-Levyt: Cancer prevention: Vaccination; 29 Hans-Joerg Senn, Nadir Arber, and Dirk Schrijvers: Cancer prevention: Chemoprevention; 30 Andrew Evans, Simon Herrington, and Robert Steele: Population cancer screening; 31 Henry T. Lynch, Carrie L. Snyder, and Jane F. Lynch (deceased): Familial cancer syndromes and genetic counselling; Section 5: Support for the cancer patient; 32 David Hui and Eduardo Bruera: Supportive palliative care; 33 Neil Aaronson and Peter Fayers: Quality of life; 34 Rachel L. Yung and Ann H. Partridge: Cancer survivorship and rehabilitation; Section 6: Disease; 35 Christine Chung, Andreas Dietz, Vincent Gregoire, Marco Guzzo, Marc Hamoir, Rene Leemans, Jean-Louis Lefebvre, Lisa Licitra, Adel El-Naggar, Brian O?Sullivan, Bing Tan, Vincent Vandecaveye, Vincent Vander Poorten, Jan Vermorken, and Michelle Williams: Cancer of the head and neck; 36 Eric Van Cutsem, Christophe M. Deroose, Piet Dirix, Karin Haustermans, Tony Lerut, Philippe Nafteux, Hans Prenen, and Xavier Sagaert: Oesophageal cancer; 37 Hideaki Bando, Takahiro Kinoshita, Yasutoshi Kuboki, Atsushi Ohtsu, and Kohei Shitara: Gastric cancer; 38 Regina Beets-Tan, Bengt Glimelius, and Lars Pahlman: Rectal cancer; 39 John Zalcberg, Stephen Fox, Alexander Heriot, Jon Knowles, Sam Ngan, Michael Michael, Kathryn Field, and Iris Nagtegaal: Colon cancer; 40 J. Weitz, M.W. Buchler, Paul D Sykes, John P Neoptolemos, Eithne Costello, Christopher M Halloran, Frank Bergmann, Peter Schirmacher, Ulrich Bork, Stefan Fritz, Jens Werner, Thomas Brunner, Elizabeth Smyth, David Cunningham, Brian R. Untch, and Peter J. Allen: Pancreatic cancer; 41 Graeme J Poston, Nicholas Stern, Jonathan Evans, Priya Healey, Daniel Palmer, and Mohandas K. Mallath: Hepatobiliary cancer; 42 H. Richard Alexander, Jr., Dario Baratti, Terence C. Chua, Marcello Deraco, Raffit Hassan, Marzia Pennati, Federica Perrone, Paul H. Sugarbaker, Anish Thomas, Keli Turner, Tristan D. Yan and Nadia Zaffaroni: Peritoneal mesothelioma; 43 Martine Piccart, Toral Gathani, Dimitrios Zardavas, Hatem A. Azim Jr., Christos Sotiriou, Giuseppe Viale, Emiel J T Rutgers, Mechthild Krause, Monica Arnedos, Suzette Delaloge, Fabrice Andre, and Felipe Ades: Cancer of the breast; 44 Richard Potter, Shujuan Liu, Bolin Liu, Sebastien Gouy, Sigurd Lax, Eric Leblanc, Philippe Morice, Fabrice Narducci, Alexander Reinthaller, Maximilian P Schmid, Catherine Uzan, and Pauline Wimberger: Gynaecological cancers; 45 John Fitzpatrick, Asif Muneer , Jean de la Rosette, and Thomas Powles: Genitourinary cancer; 46 Rafal Dziadziuszko, Michael Baumann, Tetsuya Mitsudomi, Keith M. Kerr, Solange Peters, and Stefan Zimmermann: Lung cancer; 47 Rebecca Butof, Axel Denz, Gustavo Baretton, Jan Stohlmacher-Williams, and Michael Baumann: Neoplasms of the thymus; 48 Andrea S. Wolf, Assunta De Rienzo, Raphael Bueno, Lucian R. Chirieac, Joseph Corson, Elizabeth H. Baldini, David Jackman, Ritu Gill, Walter Weder, Isabelle Opitz, Ann S. Adams, and David J. Sugarbaker: Pleural mesothelioma; 49 John F Thompson, Richard A Scolyer, and Richard F Kefford: Skin cancer: melanoma; 50 Diona L. Damian, Richard A. Scolyer, Graham Stevens, Alexander Menzies, and John F. Thompson: Skin cancer: non-melonoma; 51 Adele K. Fielding, Charles G. Mullighan, Dieter Hoelzer, Eytan M. Stein, Ghada Zakout, Martin S. Tallman, Ross Levine, Yishai Ofran, Jacob M. Rowe, and Ross L. Levine: Acute leukemia; 52 Hemant Malhotra, Lalit Kumar, Pankaj Malhotra, Devendra Hiwase, and Ravi Bhatia: Chronic leukemias; 53 Charlotte Pawlyn, Faith Davies, and Gareth Morgan: Myeloma; 54 Frank Kroschinsky, Friedrich Stolzel, Stefano A. Pileri, Bjoern Chapuy, Rainer Ordemann, Christian Gisselbrecht, Tim Illidge, David C. Hodgson, Mary K. Gospodarowicz, Christina Schutze, and Gerald Wulf: Lymphomas; 55 Alessandro Gronchi, Angelo P. Dei Tos, and Paolo G. Casali: Sarcomas of the soft tissue; 56 Puneet Plaha, Allyson Parry, Pieter Pretorius, Michael Brada, Olaf Ansorge, and Claire Blessing: Cancer of the central nervous system; 57 Daniel G. Ezra, Geoffrey E. Rose, Jacob Pe'er, Sarah Coupland, S. Seregard, G.P.M. Luyten, and Annette C. Moll: Cancer of the eye and orbit; 58 David Kerr, Andrew Weaver, Anthony P. Weetman, Oliver Gimm, Ashley Grossman, Petra Sulentic, Bertram Wiedenmann, Ulrich-Frank Pape, John Wass, Angela Rogers, and W de Herder: Endocrine cancers; 59 Nicholas Pavlidis and George Pentheroudakis: Cancer of unknown primary site; Index