Scientific Principles of Adipose Stem Cells

Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine. Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included.

Part 1 Introduction and front matter1. Plastic surgery, fat, and fat plasticity: How adipose tissue changed the landscape of stem cell therapeuticsLauren Kokai and J. Peter RubinPart 2 Basic biology of adipose stem cells2. Developmental origins of adipocytes: What we learn from human pluripotent stem cells Xi Yao, Vincent Dani, and Christian Dani3. Establishing the adipose stem cell identity: Characterization assays and functional propertiesMark A.A. Harrison, Sara I. Al-Ghadban, Benjamen T. O'Donnell, Omair A. Mohiuddin, Rachel M. Wise, Brianne N. Sullivan, and Bruce A. Bunnell4. Insights into the adipose stem cell niche in health and diseaseAaron C. Brown5. Mechanisms of adipose-derived stem cell aging and the impact on therapeutic potentialXiaoyin Shan and Ivona Percec6. Human pluripotent nontumorigenic multilineage differentiating stress enduring (Muse) cells isolated from adipose tissue: A new paradigm in regenerative medicine and cell therapyKaren L. Leung and Gregorio D. Chazenbalk7. Adipose stem cell homing and routes of delivery Ganesh Swaminathan, Yang Qiao, Bhavesh D. Kevadiya, Lucille A. Bresette, Daniel D. Liu, and Avnesh S. Thakor8. Bioreactors and microphysiological systems for adipose-based pharmacologic screeningMallory D. Griffin and Rosalyn D. AbbottPart 3  Adipose cell therapy and regenerative medicine9. Adipose stem cells and donor demographics: Impact of anatomic location, donor sex, race, BMI, and healthAdam Cottrill, Yasamin Samadi, and Kacey G. Marra10. Immunomodulatory properties of adipose stem cells in vivo: Preclinical and clinical applicationsMatthias Waldner, Fuat Baris Bengur, and Lauren Kokai11. Clinical experience with adipose tissue enriched with adipose stem cellsShawn Loder, Danielle Minteer, and J. Peter Rubin12. Adipose-derived stem cells for wound healing and fibrosisY Samadi, FM Egro, RL Rodriguez, and A Ejaz13. Oncologic safety of adipose-derived stem cell applicationHakan Orbay and David E. Sahar14. FDA regulation of adipose cell use in clinical trials and clinical translationMary Ann Chirba, Veronica Morgan Jones, Patsy Simon, and Adam J. KatzPart 4 Engineering with adipose stem cell15. Biomaterial control of adipose-derived stem/stromal cell differentiationJohn Walker and Lauren Flynn16. Genetic modification of adipose-derived stem cells for bone regenerationHarsh N. Shah, Abra H. Shen, Sandeep Adem, Ankit Salhotra, Michael T. Longaker, and Derrick C. Wan17. Adipose-derived stromal/stem cells for bone tissue engineering applicationsNathalie Faucheux, Fabien Kawecki, Jessica Jann, Franc¿ois A. Auger, Roberto D. Fanganiello, and Julie Fradette18. The hematopoietic potential of stem cells from the adipose tissueBeatrice Cousin and Louis Casteilla19. Adipose stem cells for peripheral nerve engineeringBenjamin K. Schilling, George E. Panagis, Jocelyn S. Baker, and Kacey G. Marra