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Gpcrs
Structure, Function, and Drug Discovery
Langbeschreibung
GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer's disease, Parkinson's disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth.
Inhaltsverzeichnis
Part I GPCR structure 1. Progress in GPCR structure Determination 2. Structure, function and therapeutic potential of adhesion GPCRs 3. Structural diversity in ligand recognition by GPCRs 4. NMR-based approaches to the study of GPCRs and GPCR-ligand interactions 5. Supramolecular structure of opsins 6. Molecular determinants of GPCR oligomerization 7. Structure of G-protein-coupled receptor heteromers 8. Class A GPCR oligomerization: reasons of controversy
ISBN-13:
9780128162286
Veröffentl:
2019
Erscheinungsdatum:
12.09.2019
Seiten:
500
Autor:
Beata Jastrzebska
Gewicht:
1374 g
Format:
276x220x27 mm
Sprache:
Englisch