Translating Regenerative Medicine to the Clinic

Introduction: Regenerative Medicine for Cardiovascular Disease-A Good Start PART I: STEM CELLS:  Chapter 1: Introduction and Overview of Stem CellsChapter 2: Mechanistic Insights from Pathologic Perspective Chapter 3: Large Animal Models to Study Stem Cell TherapySection I. Body's Native Repair MechanismsChapter 4. Evolution of understanding of the mechanisms of repair     Chapter 5: Impact of Age on Stem Cell FunctionSection II: Autologous Bone MarrowChapter 6: Bone Marrow Mononuclear CellsChapter 7: Chronic Limb IschemiaChapter 8: Chronic/Refractory AnginaChapter 9: Acute Myocardial InfarctionA. European Experience:  Andreas ZeiherB. US Experience: Jay Traverse Chapter 10: Chronic Ischemic Heart FailureSection III:  Autologous Adipose Derived Regenerative CellsChapter 11: Adipose TissueSection IV: Allogeneic Alternatives to Autologous Bone MarrowChapter 12: Overview of MSCs     Chapter 13: Allogeneic vs Autologous Source: Comparative EffectsChapter 14: Use of MSCs for AMIChapter 15: Combined Cell StrategiesChapter 16: Heart FailureSection V: Cardiac Progenitor CellsChapter 17:  C-Kit+ cellsChapter 18:  CardiospheresSection VI: Other Allogeneic Sources of Stem CellsChapter 19:  Umbilical Cord, Placenta, EndometriumSection VII. Genetic Engineering/Cell TransformationChapter 20:  Genetic Engineering of Fibroblasts to CardiomyocytesChapter 21:  Transformation to inducible Pleuripotent Stem CellsChapter 22:  Transformation to MAPC'sSection VIII: METHODS OF DELIVERY:  Chapter 23.  Transcoronary and EndocardialChapter 24.  Retrograde and EpicardialPart II. TISSUE ENGINEERING:Chapter 25.  Epicardial PatchChapter 26.  Matrix ScaffoldsChapter 27.  Matrix plus cellsChapter 28.  BiomaterialChapter 29:  OrganogenesisPart III. GENE THERAPY: Chapter 30:  Pre-clinical Identification of target genesChapter 31:  SERCA-2a gene for recovery of inotropic functionChapter 32:  SDF-1 Gene for Heart Failure Non-Inotropic MechanismsChapter 33:  Gene Therapy for Angiogenesis: Chronic Limb Ischemia Chapter 34:  Stem Cells Target Gene Transfected Stem CellsPart IV: FUTURE DIRECTIONS:Chapter 35:  CCTRN: Past, Present, and Vision for the FutureChapter 36:  Signature of Responders-lessons from Bio-RepositoryChapter 37:  Adjunctive therapy with LVADs for RecoveryChapter 38:  Trials in Non-Ischemic Heart Failure  Chapter 39:  Enhancing Stem Cell Homing for Tissue RepairChapter 40:  Stroke: Pre-Clinical and Clinical Trial DataSUMMARY