Principles of Bone Biology

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders.

Part I Basic Principles A. Cell Biology Chapter 1:  Structure, Modeling and Remodeling of Bone / The Size and Shape of Bone as a Site of Metabolic Bone Activity Chapter 2: Biomechanics of Bone Chapter 3: Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation Chapter 4: Mesenchymal Stem Cells & Osteoblast Lineage Chapter 5: Transcriptional Control of Osteoblast Differentiation and Function Chapter 6: Wnt Signaling and Bone Chapter 7: Sclerostin and Bone Chapter 8: The Osteocyte Chapter 9: Cells of Bone: Osteoplast Generation Chapter 10: Osteoclast Function: Biology and Mechanisms Chapter 11: RANK Signaling Chapter12: Regulating Bone Resorption Chapter 13: Apoptosis in Bone Cells Chapter 14: Skeletal Gene Expression in Nuclear Microenvironments B. Biochemistry Chapter 15:  Type I Collagen: Structure, Synthesis, and Regulation Chapter 16: Collagen Crosslinking & Metabolism Chapter 17: Bone Matrix Proteoglycans & Glycoproteins Chapter 18: Osteopontin Chapter 19: Bone Proteinases Chapter 20: Integrins and Other Cell Surface Attachment Molecules of Bone Cells Chapter 21: Intercellular Junctions and Cell-Cell Communication in the Skeletal System C. Bone Remodeling and Mineral Homeostasis Chapter 22: Histomorphometric Analysis of Bone Remodeling Chapter 23: Phosphorus Homeostasis & Related Disorders Chapter 24: Magnesium Homeostasis Chapter 25: Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Stro Chapter 26: Biology of the Extracellular Ca2+-Sensing Receptor D. The Hormones of Bone Chapter 27: Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein Chapter 28: Parathyroid Hormone - Molecular Biology Chapter 29: Parathyroid Hormone-Receptor Interactions Chapter 30: Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System Chapter 31: The Vascular and Cardiovascular Actions of PTH Chapter 32: PTH and PTHrP Actions on Kidney and Bone Chapter 33: Physiological Actions of Parathyroid Hormone and PTH-Related Protein Chapter 34: Vascular, Cardiovascular and Neurological Actions of Parathyroid-Related Protein Chapter 35: Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses Chapter 36: Vitamin D Gene Regulation Chapter 37: Photobiology and Non-Calcemic Actions of Vitamin D Chapter 38: Calcitonin Structure and Molecular Biology of the Calcitonin Receptor / Calcitonin Gene Family and Receptors: Structure, Molecular Biology, and Effects Chapter 39: Amylin and Calcitonin Gene-Related Peptide E. Other Systemic Hormones That Influence Bone Metabolism Chapter 40: Estrogens & Progestins Chapter 41: The Pharmacology of Selective Estrogen Receptor Modulators Chapter 42: Mechanisms of Estrogen Action in Bone Chapter 43: Thyroid Hormone & Bone Chapter 44: Clinical and Basic Aspects of Glucocorticoid Action in Bone Chapter 45: Effects of Diabetetes & Insulin on Bone Physiology Chapter 46: Androgens:Receptor Expression and Steroid Action in Bone Chapter 47: Kinins & Neuro-Osteogenic Factors Chapter 48: Regulation of Bone Remodeling by Central and Peripheral Nervous Signals Patricia Ducy F. Local Regulators Chapter 49: Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology Chapter 50: Platelet-Derived Growth Factor & the Skeleton Chapter 51: Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone Chapter 52: Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling Chapter 53: Transforming Growth Factor-â Chapter 54: Bone Morphogenetic Proteins and the Skeleton Chapter 55: Bone Morphogenetic Protein Receptors & Actions Chapter 56: Colony-Stimulating Factor-1 Chapter 57: Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines Chapter 58: Prostaglandins & Bone Metabolism Carol Pilbeam Part II Molecular Mechanisms of Metabolic Bone Disease Chapter 59: Skeletal Effects of Nitric Oxide: Novel Agent for Osteoporosis Chapter 60: Molecular Basis of PTH Overexpression Chapter 61: Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism Chapter 62: Multiple Endocrine Neoplasia Type I Chapter 63: Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy Chapter 64: Local Factors in Skeletal Malignancy Chapter 65: Genetic Regulation of the Parathyroid Gland Development Chapter 66: Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations Chapter 67: Diseases Resulting from Defects in the G Protein Gs Chapter 68: Renal Osteodystrophy - Pathogenic Mechanisms and Therapeutic Options Chapter 69: Osteogenesis Imperfecta Chapter 70: Hereditary Deficiencies in Vitamin D Action Chapter 71: Oncogenic Osteomalacia Chapter 72: Osteopetrosis Chapter 73: Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans Chapter 74: Paget's Disease of Bone Chapter 75: Genetic Determinants of Bone Mass and Osteoporotic Fracture Chapter 76: Pathophysiology of Osteoporosis Chapter 77: Evaluation of Risk for Osteoporosis Fracture Part III Pharmacological Mechanisms of Therapeutics Chapter 78: Parathyroid Hormone Chapter 79: Calcium Chapter 80: Drugs Acting on the Calcium Receptor Calcimimetics and Calcilytics Chapter 81: Bisphosphonates: Mechanisms of Action Chapter 82: The Pharmacology of Estrogens in Osteoporosis Chapter 83: Vitamin D & Analogs Chapter 84: Estrogen Effects on Bone in the Male Skeleton Chapter 85: Mechanisms of Exercise Effects on Bone Quantity and Quality