Principles of Bone Biology

Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics.The most current and timely source of information about the biology and pathology of boneProvides succinct coverage of the subjectContributors include over 200 of the most respected researchers in the fieldExtensive table of contents and index for easy referenceEasy-to-read and highly informative to both the newcomer and the initiated to the field Spans the spectrum from molecular biology to in vivo pharmacologyComplete bibliography with each entry fully referenced for additional background reading First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996

PART I: BASIC PRINCIPLESCell BiologyThe Structure & Development of the SkeletonBiomechanics of BoneEmbryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone FormationMesenchymal Stem Cells & Osteoblast LineageTranscriptional Control of Osteoblast Differentiation and FunctionThe OsteocyteCells of Bone: Osteoclast GenerationOsteoclast FunctionIntegrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Function of OsteoclastsApoptosis in Bone CellsInvolvement of Nuclear Architecture in Regulating Gene Expression in Bone CellsBiochemistryType I Collagen: Structure, Synthesis, and RegulationCollagen Crosslinking & MetabolismBone Matrix Proteoglycans & GlycoproteinsOsteopontinBone ProteinasesCell Surface Attachment MoleculesIntercellular Junctions and Cell-Cell Communication in BoneBone Remodeling and Mineral HomeostasisHistomorphometric Analysis of Bone RemodelingPhosphorus Homeostasis & Related DisordersMagnesium HomeostasisMetals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & StrontiumThe Biology of the Extracellular Ca2+-Sensing Receptor (CaR)The Hormones of BoneReceptors for Parathyroid Hormone and Parathyroid Hormone-Related PeptideParathyroid Hormone - Molecular BiologyParathyroid Hormone-Receptor InteractionsActions of Parathyroid HormoneRenal and Skeletal Actions of PTH and PTHrPPhysiological Actions of PTH and PTHRP: Epidermal, Mammary, Reproductive and Pancreatic IssuesVascular, Cardiovascular and Neurological Actions of PTHrPNuclear Receptor Structure (VDR) and Ligand Specificities for Genomic and Rapid Biological ResponsesVitamin D Gene RegulationPhotobiology and Non-Calcemic Actions of Vitamin DThe Structure and Molecular Biology of the Calcitonin ReceptorPhysiology & Pathophysiology of CalcitoninAmylin & CGRPOther Systemic Hormones That Influence Bone MetabolismEstrogens & ProgestinsSelective Estrogen Receptor Modulators (SERMs)Mechanisms of Estrogen Action in BoneThyroid Hormone & BoneClinical and Basic Aspects of Glucocorticoid Action in BoneEffects of Diabetes & Insulin on Bone PhysiologyAndrogens: Receptor Expression and Steroid Action in BoneKinins & Neuro-Osteogenic FactorsLocal RegulatorsThe Role of Insulin-like Growth Factors & Binding Proteins in Bone Cell BiologyPlatelet-Derived Growth Factor & the SkeletonFibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in BoneVascular Endothelial Growth FactorsTransforming Growth Factor (beta)Bone Morphogenetic ProteinsBone Morphogenetic Protein Receptors & ActionsColony-Stimulating FactorsLocal Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional CytokinesProstaglandins & Bone MetabolismNitric Oxide and other Vasoactive AgentsPART II: MOLECULAR MECHANISMS OF METABOLIC BONE DISEASESMolecular Basis of PTH OverexpressionFamilial Benign Hypocalciuric Hypercalcemia and Neonatal Primary HyperparathyroidismMultiple Endocrine Neoplasia Type IThe Role of the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2Systemic Factors in Skeletal Manifestations of MalignancyLocal Factors in Skeletal MalignancyMolecular Basis of PTH UnderexpressionJansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor MutationsSignal Transduction via G Proteins; PseudohypoparathyroidismOther Skeletal Diseases Resulting from G Protein Defects - Fibrous Dysplasia & McCune-Albright SyndromeOsteogenesis ImperfectaHereditary Deficiencies in Vitamin D Action.Oncogenic OsteomalaciaOsteopetrosisHypophosphatasia: Nature's Window on Alkaline Phosphatase Function in ManPaget's Disease of BoneGenetic Determinants of Bone MassPathophysiology of OsteoporosisEvaluation of Risk for Osteoporosis FracturesPART III: PHARMACOLOGIC MECHANISMS OF THERAPEUTICSPharmacologic Mechanisms of Therapeutics: Parathyroid HormoneCalciumCalcium Receptors as Novel Drug TargetsBisphosphonates: Mechanisms of ActionFluoride in OsteoporosisThe Pharmacology of Estrogens in OsteoporosisPharmacologic Mechanisms of Therapeutics: Vitamin D & AnalogsMolecular and Clinical Pharmacology of CalcitoninGrowth Hormone and Insulin-like Growth Factor-I Treatment for Metabolic Bone DiseasesAnabolic Steroid Effects on Bone in WomenEstrogen Effects on Bone in the Male SkeletonMechanisms of Exercise Effects on BonePART IV: METHODS IN BONE RESEARCHApplication of Transgenic Mice to Problems of Skeletal BoneUse of Cultured Osteoblastic Cells to Identify and Characterize Transcriptional Regulatory ComplexesCurrent Methodologic Issues in Cell & Tissue CultureBiochemical Markers of Bone MetabolismMethods and Clinical Issues in Bone Densitometry and Quantitative UltrasonometryControversies in Bone Mass MeasurementMacro and Micro Imaging of Bone ArchitectureTransilial Bone BiopsyAnimal Models in Osteoporosis ResearchDefining the Genetics of Osteoporosis - Using the Mouse to Understand Man